Protein Misfolding and Neurodegeneration
نویسندگان
چکیده
منابع مشابه
Protein misfolding and neurodegeneration.
A key molecular pathway implicated in diverse neurodegenerative diseases is the misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence strongly supports the hypothesis that accumulation of misfolded proteins leads to synaptic dysfunction, neuronal apoptosis, brain damage, and disease. However, the mechanism by which protein misfolding and aggregation trigger neu...
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Introduction The proteins are manifestation of the genetic functions and are central to various biological processes. Misfolded proteins may lead to pre-fibrillar assemblies and and can cause destabilizing mutations on disease proteins. Protein folding has been studied in detail by both experimental and theoretical methods (Soto & Estrada, 2008). Human diseases characterized by insoluble deposi...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2008
ISSN: 0003-9942
DOI: 10.1001/archneurol.2007.56